Arthro Aid Direct Cream contains glucosamine and shark cartilage to provide relief from the pain of many arthritic conditions and in particular Osteoarthritis. Derived from seafood. If you are allergic to seafood, do not take arthro aid direct cream. Arthro Aid Direct Cream contains glucosamine and shark cartilage to provide relief from the pain of many arthritic conditions and in particular Osteoarthritis. This product provides effective temporary relief within 6 minutes of application and its unique delivery system aids in rapid skin absorption.