Skin Doctors Skin Renew Cooling Face Serum contains alpine rose stem cells, hyaluronic acid and peppermint oil to help repair and rejuvenate the skin and boost collagen and elastin production, as well as Reneseed to accelerate the rate of cell turnover in the skin and cooling peppermint oil. Age-related reduction of skin collagen can begin to accelerate quickly during menopause. Within the first five years of menopause, the skin loses around 30 percent of its collagen, which can lead to a loss of skin firmness, the appearance of deeper facial wrinkles and increased fine lines. Changing hormone levels can accelerate melanin production, resulting in pigmentation and uneven skin tone across the face, neck and decolletage. Reduced oestrogen levels can additionally cause an over production of sebum in the skin, which can lead to larger, clogged pores and blemished skin. Age-defying cooling face serum designed for women 45 plus to begin use during perimenopause when initial skin changes are first noticed, in order to help boost the skin’s elasticity and firmness, plump out fine lines and wrinkles and calm skin dryness and redness throughout the day.